MeSH Browser

MeSH Heading: NLR Proteins
Tree Number(s): D12.644.360.539
Unique ID: D000070576
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000070576
Scope Note: Intracellular signaling proteins that are defined by the presence of a NUCLEOTIDE-binding region and LEUCINE-rich repeats. Their general structure consists of any of a variety of effector domains at their N-termini such as a caspase recruitment domain (CARD), a central nucleotide-binding domain, and a variable number of C-terminal leucine-rich repeats. They are important for pathogen recognition in the INNATE IMMUNE RESPONSE of animals and plants. Members of the NLR protein family include the NOD SIGNALING ADAPTOR PROTEINS.
Entry Term(s): NLR Protein; NOD-like Receptor; NOD-like Receptors; Nucleotide-Binding Domain Leucine-Rich Repeat Protein; Nucleotide-binding Domain Leucine-rich Repeat Proteins
Previous Indexing: Nod Signaling Adaptor Proteins (2007-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000610980
Scope Note: Intracellular signaling proteins that are defined by the presence of a NUCLEOTIDE-binding region and LEUCINE-rich repeats. Their general structure consists of any of a variety of effector domains at their N-termini such as a caspase recruitment domain (CARD), a central nucleotide-binding domain, and a variable number of C-terminal leucine-rich repeats. They are important for pathogen recognition in the INNATE IMMUNE RESPONSE of animals and plants. Members of the NLR protein family include the NOD SIGNALING ADAPTOR PROTEINS.
Terms: NLR Proteins Preferred Term
Term UI T000888166
Date10/19/2015
LexicalTag ABX
ThesaurusID NLM (2017); Nucleotide-Binding Domain Leucine-Rich Repeat Protein
Term UI T000998950
Date11/21/2019
LexicalTag NON
ThesaurusID NLM (2021); Nucleotide-binding Domain Leucine-rich Repeat Proteins
Term UI T000888167
Date10/19/2015
LexicalTag NON
ThesaurusID NLM (2017); NLR Protein
Term UI T000888168
Date10/19/2015
LexicalTag ABX
ThesaurusID NLM (2017); NOD-like Receptor
Term UI T000998951
Date11/21/2019
LexicalTag NON
ThesaurusID NLM (2021); NOD-like Receptors
Term UI T000888573
Date10/27/2015
LexicalTag ABX
ThesaurusID NLM (2017)

NLR Proteins MeSH Descriptor Data 2024