- Concept UI
- M0493381
- Registry Numbers
- 0
- Scope Note
- Cytosolic signaling adaptor proteins that were initially discovered by their role in the innate immunity (IMMUNITY, INNATE) response of organisms that lack an adaptive immune system. This class of proteins contains three domains, a C-terminal ligand recognition domain, an N-terminal effector-binding domain, and a centrally located nuclear-binding oligomerization domain. Many members of this class contain a C-terminal leucine rich domain which binds to PEPTIDOGLYCAN on the surface of BACTERIA and plays a role in pathogen resistance.
- Terms
-
Nod Signaling Adaptor Proteins
Preferred Term
Term UI
T663300
Date12/28/2005
LexicalTag
ACX
ThesaurusID
NLM (2007)
-
Nuclear-Binding Oligomerization Domain Proteins
Term UI
T663305
Date12/28/2005
LexicalTag
NON
ThesaurusID
NLM (2007)
-
Nucleotide Oligomerization Domain Proteins
Term UI
T666902
Date02/23/2006
LexicalTag
NON
ThesaurusID
NLM (2007)