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Nod2 Signaling Adaptor Protein MeSH Descriptor Data 2023


MeSH Heading
Nod2 Signaling Adaptor Protein
Tree Number(s)
D12.644.360.024.131.500
D12.644.360.024.313.500
D12.644.360.075.358.500
D12.644.360.539.500.500
D12.776.157.057.006.500
D12.776.157.057.078.500
D12.776.476.024.139.500
D12.776.476.024.391.500
D12.776.476.075.358.500
Unique ID
D053473
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D053473
Scope Note
A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.
Entry Term(s)
CARD15 Protein
Caspase Recruitment Domain Protein 15
Nucleotide Oligomerization Domain 2 Protein
Registry Number
0
Previous Indexing
Carrier Proteins (2001-2004)
Intracellular Signaling Peptides and Proteins (2005-2006)
Public MeSH Note
2007
History Note
2007
Date Established
2007/01/01
Date of Entry
2006/07/05
Revision Date
2016/03/30
Nod2 Signaling Adaptor Protein Preferred
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