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Caspases MeSH Descriptor Data 2022


MeSH Heading
Caspases
Tree Number(s)
D08.811.277.656.262.500.126
D08.811.277.656.300.200.126
D12.776.476.075.405
Unique ID
D020169
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D020169
Annotation
CASPASES, EFFECTOR and CASPASES, INITIATOR and specifics are available
Scope Note
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
Entry Term(s)
Caspase
Registry Number
EC 3.4.22.-
Previous Indexing
Cysteine Proteinases (1997-1998)
See Also
Apoptosis
Public MeSH Note
99
History Note
99
Entry Combination
antagonists & inhibitors:Caspase Inhibitors
Date Established
1999/01/01
Date of Entry
1998/06/10
Revision Date
2021/05/21
Caspases Preferred
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