MeSH Browser

MeSH Heading: 3C Viral Proteases
Tree Number(s): D08.811.277.656.262.500.108; D08.811.277.656.979.250; D12.776.964.900.500.500
Unique ID: D000086042
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000086042
Scope Note: A class of cysteine proteases which play an essential role in VIRUS REPLICATION. They cleave precursor viral POLYPROTEINS to produce functional proteins and enzymes. In addition, they cleave certain host cell proteins such as EUKARYOTIC INITIATION FACTOR-4G.
Entry Term(s): 3C Proteases; 3C Proteinases; 3C-like Viral Proteases; 3Cpro Proteinases
Registry Numbers: EC 3.4.22.28; EC 3.4.22.28
Related Numbers: EC 3.4.22.28
Previous Indexing: Peptide Hydrolases (1966-2020); Viral Proteins (1965-2020)
Public MeSH Note: 2021
History Note: 2021
Date Established: 2021/01/01
Date of Entry: 2020/07/07
Revision Date: 2023/06/12

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000731725
Registry Numbers: EC 3.4.22.28
Related Numbers: EC 3.4.22.28
Scope Note: A class of cysteine proteases which play an essential role in VIRUS REPLICATION. They cleave precursor viral POLYPROTEINS to produce functional proteins and enzymes. In addition, they cleave certain host cell proteins such as EUKARYOTIC INITIATION FACTOR-4G.
Terms: 3C Viral Proteases Preferred Term
Term UI T001078484
Date04/14/2020
LexicalTag NON
ThesaurusID NLM (2021); 3C Proteinases
Term UI T001136610
Date04/20/2023
LexicalTag NON
ThesaurusID NLM (2024); 3C Proteases
Term UI T001136609
Date04/20/2023
LexicalTag NON
ThesaurusID NLM (2024); 3Cpro Proteinases
Term UI T001081106
Date05/21/2020
LexicalTag ABX
ThesaurusID NLM (2021)

3C Viral Proteases MeSH Descriptor Data 2025