MeSH Browser

MeSH Heading: Calpain
Tree Number(s): D08.811.277.656.262.500.120; D08.811.277.656.300.200.120
Unique ID: D002154
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D002154
Annotation: /biosyn /‌physiol permitted
Scope Note: Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.
Entry Term(s): Ca2+-Activated Protease; Calcium-Activated Neutral Protease; Calcium-Activated Neutral Proteinase; Calcium-Activated Protease; Calcium-Dependent Neutral Protease; Calcium-Dependent Neutral Proteinase; Calpain I; Calpain II; Desminase
Registry Numbers: EC 3.4.22.-; EC 3.4.22.52; EC 3.4.22.53
Related Numbers: EC 3.4.22.52; EC 3.4.22.53
NLM Classification #: QU 136
Previous Indexing: Peptide Peptidohydrolases (1966-1985)
Public MeSH Note: 86
History Note: 86
Date Established: 1986/01/01
Date of Entry: 1985/04/25
Revision Date: 2016/06/28

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Cysteine Proteases [D08.811.277.656.262]
        
        Cysteine Endopeptidases [D08.811.277.656.262.500]
        
        Bromelains [D08.811.277.656.262.500.096]
        
        3C Viral Proteases [D08.811.277.656.262.500.108]
        
        Calpain [D08.811.277.656.262.500.120]
        
        Caspases [D08.811.277.656.262.500.126]
        
        Cathepsin B [D08.811.277.656.262.500.133]
        
        Cathepsin F [D08.811.277.656.262.500.146]
        
        Cathepsin H [D08.811.277.656.262.500.153]
        
        Cathepsin K [D08.811.277.656.262.500.156]
        
        Cathepsin L [D08.811.277.656.262.500.157]
        
        Cathepsin W [D08.811.277.656.262.500.158]
        
        Chymopapain [D08.811.277.656.262.500.160]
        
        Ficain [D08.811.277.656.262.500.350]
        
        Gingipain Cysteine Endopeptidases [D08.811.277.656.262.500.468]
        
        Papain [D08.811.277.656.262.500.585]
        
        Separase [D08.811.277.656.262.500.792]
        
        Viral Papain-like Proteases [D08.811.277.656.262.500.896]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Endopeptidases [D08.811.277.656.300]
        
        Cysteine Endopeptidases [D08.811.277.656.300.200]
        
        Bromelains [D08.811.277.656.300.200.096]
        
        Calpain [D08.811.277.656.300.200.120]
        
        Caspases [D08.811.277.656.300.200.126]
        
        Cathepsin B [D08.811.277.656.300.200.133]
        
        Cathepsin F [D08.811.277.656.300.200.146]
        
        Cathepsin H [D08.811.277.656.300.200.153]
        
        Cathepsin K [D08.811.277.656.300.200.156]
        
        Cathepsin L [D08.811.277.656.300.200.157]
        
        Cathepsin W [D08.811.277.656.300.200.158]
        
        Chymopapain [D08.811.277.656.300.200.160]
        
        Ficain [D08.811.277.656.300.200.350]
        
        Papain [D08.811.277.656.300.200.585]
        
        Separase [D08.811.277.656.300.200.792]

Calpain Preferred

Concept UI: M0003226
Registry Numbers: EC 3.4.22.-
Related Numbers: EC 3.4.22.52; EC 3.4.22.53
Scope Note: Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.
Terms: Calpain Preferred Term
Term UI T006164
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1986); Calcium-Activated Protease
Term UI T006162
Date04/25/1985
LexicalTag NON
ThesaurusID UNK (19XX); Calcium-Dependent Neutral Proteinase
Term UI T006163
Date04/25/1985
LexicalTag NON
ThesaurusID UNK (19XX); Desminase
Term UI T006165
Date12/08/1987
LexicalTag NON
ThesaurusID UNK (19XX); Ca2+-Activated Protease
Term UI T006166
Date04/25/1985
LexicalTag NON
ThesaurusID UNK (19XX); Calcium-Activated Neutral Proteinase
Term UI T006167
Date04/25/1985
LexicalTag NON
ThesaurusID UNK (19XX); Calcium-Activated Neutral Protease
Term UI T006161
Date04/25/1985
LexicalTag NON
ThesaurusID UNK (19XX); Calcium-Dependent Neutral Protease
Term UI T006168
Date04/25/1985
LexicalTag NON
ThesaurusID UNK (19XX)

Calpain I Narrower

Calpain II Narrower

Calpain MeSH Descriptor Data 2025