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Calpain MeSH Descriptor Data 2022


MeSH Heading
Calpain
Tree Number(s)
D08.811.277.656.262.500.120
D08.811.277.656.300.200.120
Unique ID
D002154
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D002154
Annotation
/biosyn /‌physiol permitted
Scope Note
Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.
Entry Term(s)
Ca2+-Activated Protease
Calcium-Activated Neutral Protease
Calcium-Activated Neutral Proteinase
Calcium-Activated Protease
Calcium-Dependent Neutral Protease
Calcium-Dependent Neutral Proteinase
Calpain I
Calpain II
Desminase
Registry Number
EC 3.4.22.-
Related Numbers
EC 3.4.22.52
EC 3.4.22.53
NLM Classification #
QU 136
Previous Indexing
Peptide Peptidohydrolases (1966-1985)
Public MeSH Note
86
History Note
86
Date Established
1986/01/01
Date of Entry
1985/04/25
Revision Date
2016/06/28
Calpain Preferred
Calpain II Narrower
Calpain I Narrower
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