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Separase MeSH Descriptor Data 2022


MeSH Heading
Separase
Tree Number(s)
D08.811.277.656.262.500.792
D08.811.277.656.300.200.792
D12.776.167.552
Unique ID
D064247
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D064247
Scope Note
Separase is a caspase-like cysteine protease, which plays a central role in triggering ANAPHASE by cleaving the SCC1/RAD21 subunit of the cohesin complex. Cohesin holds the sister CHROMATIDS together during METAPHASE and its cleavage results in chromosome segregation.
Registry Number
EC 3.4.22.49
Previous Indexing
Cell Cycle Proteins (1999-2013)
Endopeptidases (1999-2013)
Public MeSH Note
2014; was indexed under ENDOPEPTIDASES and CELL CYCLE PROTEINS 1999-2013
History Note
2014
Date Established
2014/01/01
Date of Entry
2013/07/08
Separase Preferred
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