Separase is a caspase-like cysteine protease, which plays a central role in triggering ANAPHASE by cleaving the SCC1/RAD21 subunit of the cohesin complex. Cohesin holds the sister CHROMATIDS together during METAPHASE and its cleavage results in chromosome segregation.
Registry Numbers
EC 3.4.22.49
Previous Indexing
Cell Cycle Proteins (1999-2013)
Endopeptidases (1999-2013)
Public MeSH Note
2014; was indexed under ENDOPEPTIDASES and CELL CYCLE PROTEINS 1999-2013
Separase is a caspase-like cysteine protease, which plays a central role in triggering ANAPHASE by cleaving the SCC1/RAD21 subunit of the cohesin complex. Cohesin holds the sister CHROMATIDS together during METAPHASE and its cleavage results in chromosome segregation.
