NLM Logo

Anaphase-Promoting Complex-Cyclosome MeSH Descriptor Data 2022


MeSH Heading
Anaphase-Promoting Complex-Cyclosome
Tree Number(s)
D08.811.464.938.750.092
D12.776.167.024
Unique ID
D064173
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D064173
Scope Note
An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.
Entry Term(s)
Anaphase Promoting Complex
Registry Number
EC 2.3.2.27
Previous Indexing
Ligases (1992-2003)
Ubiquitin-Protein Ligase Complexes (2004-2013)
Public MeSH Note
2014; was indexed under UBIQUITIN-PROTEIN LIGASE COMPLEXES 2004-2013
History Note
2014
Date Established
2014/01/01
Date of Entry
2013/07/08
Revision Date
2016/06/02
Anaphase-Promoting Complex-Cyclosome Preferred
page delivered in 0.149s