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Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein MeSH Descriptor Data 2022


MeSH Heading
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
Tree Number(s)
D08.811.277.656.262.500.126.775
D08.811.277.656.300.200.126.775
D08.811.464.938.750.233
Unique ID
D000074884
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000074884
Scope Note
A caspase-like cysteine endopeptidase that also exhibits ubiquitin ligase activity. It contains an N-terminal DEATH DOMAIN, two IMMUNOGLOBULIN-LIKE DOMAINS, and localizes to the perinuclear region of MONOCYTES, where it functions in activation of NF-KAPPA B; it also binds to and activates TRAF6. Chromosomal translocations involving the MALT1 and BIRC2 genes are associated with MALT LYMPHOMA, and mutations in the MALT1 gene are associated with Type 12 IMMUNODEFICIENCY SYNDROMES.
Entry Term(s)
MALT-1 Protein
MALT1 Paracaspase
MALT1 Protein
Paracaspase
Registry Number
EC 3.4.22.-
Previous Indexing
Caspases (1999-2017)
Neoplasm Proteins (1999-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/05/22
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein Preferred
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