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Tripartite Motif-Containing Protein 28 MeSH Descriptor Data 2022


MeSH Heading
Tripartite Motif-Containing Protein 28
Tree Number(s)
D08.811.464.938.750.782
D12.776.260.703.675
D12.776.930.780.911
D12.776.934.875
Unique ID
D000076183
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000076183
Scope Note
A tripartite motif protein consisting of an N-terminal RING finger, two B-box type ZINC FINGERS, and C-terminal PHD domain. It functions as a transcriptional repressor by associating with Kruppel-association box domain (KRAB domain) transcription factors and has E3-SUMO-ligase activity towards itself and also sumoylates INTERFERON REGULATORY FACTOR-7 to reduce its activity as a transcriptional activator. It can also function as a ubiquitin protein ligase towards TUMOR SUPPRESSOR PROTEIN P53.
Entry Term(s)
TRIM28 Protein
Registry Number
EC 2.3.2.27
Previous Indexing
Repressor Proteins (2004-2017)
See Also
PHD Zinc Fingers
RING Finger Domains
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/06/29
Tripartite Motif-Containing Protein 28 Preferred
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