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CCCTC-Binding Factor MeSH Descriptor Data 2023


MeSH Heading
CCCTC-Binding Factor
Tree Number(s)
D12.776.157.687.157
D12.776.260.120
D12.776.660.235.050
D12.776.660.720.157
D12.776.664.235.050
D12.776.930.780.563
Unique ID
D000076246
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000076246
Scope Note
A repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING.
Entry Term(s)
CTCF Protein
DNA-Binding Protein CTCF
Registry Number
0
Public MeSH Note
2018; CCCTC-BINDING FACTOR was indexed under REPRESSOR PROTEINS 2010-2017, under DNA-BINDING PROTEINS 1998-2009; and under TRANSCRIPTION FACTORS 1998-2004
History Note
2018 (1998)
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/06/29
CCCTC-Binding Factor Preferred
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