- Concept UI
- M0284805
- Registry Numbers
- 0
- Scope Note
- A repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING.
- Terms
-
CCCTC-Binding Factor
Preferred Term
Term UI
T000925898
Date06/01/2017
LexicalTag
ABX
ThesaurusID
NLM (2004)
-
CTCF Protein
Term UI
T000925899
Date06/01/2017
LexicalTag
ABX
ThesaurusID
NLM (1998)
-
DNA-Binding Protein CTCF
Term UI
T000925900
Date06/01/2017
LexicalTag
ABX
ThesaurusID
NLM (2004)