MeSH Browser

MeSH Heading: CCCTC-Binding Factor
Tree Number(s): D12.776.157.687.157; D12.776.260.120; D12.776.660.235.050; D12.776.660.720.157; D12.776.664.235.050; D12.776.930.780.563
Unique ID: D000076246
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000076246
Scope Note: A repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING.
Entry Term(s): CTCF Protein; DNA-Binding Protein CTCF
Public MeSH Note: 2018; CCCTC-BINDING FACTOR was indexed under REPRESSOR PROTEINS 2010-2017, under DNA-BINDING PROTEINS 1998-2009; and under TRANSCRIPTION FACTORS 1998-2004
History Note: 2018 (1998)
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0284805
Scope Note: A repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING.
Terms: CCCTC-Binding Factor Preferred Term
Term UI T000925898
Date06/01/2017
LexicalTag ABX
ThesaurusID NLM (2004); CTCF Protein
Term UI T000925899
Date06/01/2017
LexicalTag ABX
ThesaurusID NLM (1998); DNA-Binding Protein CTCF
Term UI T000925900
Date06/01/2017
LexicalTag ABX
ThesaurusID NLM (2004)

CCCTC-Binding Factor MeSH Descriptor Data 2024