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Positive Regulatory Domain I-Binding Factor 1 MeSH Descriptor Data 2023


MeSH Heading
Positive Regulatory Domain I-Binding Factor 1
Tree Number(s)
D08.811.913.555.500.800.700
D12.776.260.703.650
D12.776.930.780.904
Unique ID
D000074462
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000074462
Scope Note
A transcriptional repressor protein that contains an N-terminal PR-SET domain, four C-terminal CYS2-HIS2 ZINC FINGERS, and binds the PRDI element in the INTERFERON-BETA gene. It has methyltransferase activity and mediates gene transcription in tissue-specific innate and adaptive immune lymphocyte T-CELLS, repressing expression of proteins that promote exit of these tissue-specific T-cell populations from non-lymphoid organs.
Entry Term(s)
B Lymphocyte-Induced Maturation Protein 1
BLIMP1 Protein
PRDI-BF1 Protein
PRDM1 Protein
Registry Number
EC 2.1.1.-
Previous Indexing
Repressor Proteins (1994-2017)
See Also
PR-SET Domains
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/06/02
Positive Regulatory Domain I-Binding Factor 1 Preferred
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