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Zinc Finger Protein Gli3 MeSH Descriptor Data 2022


MeSH Heading
Zinc Finger Protein Gli3
Tree Number(s)
D12.776.260.522.875
D12.776.260.703.900
D12.776.930.375.875
D12.776.930.780.972
Unique ID
D000074290
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000074290
Scope Note
A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.
Entry Term(s)
GLI-Kruppel Family Member 3 Protein
Glioma-Associated Oncogene Family Zinc Finger 3 Protein
Registry Number
0
Previous Indexing
DNA-Binding Proteins (1990-2017)
Kruppel-Like Transcription Factors (2006-2017)
Nerve Tissue Proteins (2006-2017)
Transcription Factors (1990-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/02/27
Zinc Finger Protein Gli3 Preferred
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