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Promyelocytic Leukemia Zinc Finger Protein MeSH Descriptor Data 2022


MeSH Heading
Promyelocytic Leukemia Zinc Finger Protein
Tree Number(s)
D12.776.260.522.625
D12.776.930.375.625
Unique ID
D000075722
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000075722
Scope Note
A Kruppel-type transcription factor consisting of an N-terminal BTB DOMAIN and nine CYS2-HIS2 ZINC FINGERS. It localizes to the nucleus and regulates cell cycle progression and gene expression for tissue development and homeostasis; it may also function as an epigenetic regulator through its interactions with HISTONE DEACETYLASE. Genetic rearrangements involving the ZBTB16 gene are associated with ACUTE PROMYELOCYTIC LEUKEMIA.
Entry Term(s)
PLZF Protein
Promyelocytic Leukaemia Zinc Finger Protein
ZBTB16 Protein
Zinc Finger and BTB Domain Containing 16 Protein
Registry Number
0
Previous Indexing
Kruppel-Like Transcription Factors (1995-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2018/05/21
Promyelocytic Leukemia Zinc Finger Protein Preferred
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