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Histone Deacetylases MeSH Descriptor Data 2022


MeSH Heading
Histone Deacetylases
Tree Number(s)
D08.811.277.087.520
Unique ID
D006655
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D006655
Scope Note
Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.
Entry Term(s)
Class I Histone Deacetylases
Class II Histone Deacetylases
HDAC Proteins
Histone Deacetylase
Histone Deacetylase Complexes
Registry Number
EC 3.5.1.98
Related Numbers
EC 3.5.1.98
Previous Indexing
Acetic Acids (1971-1974)
Amidohydrolases (1971-1974)
Histones (1971-1974)
Public MeSH Note
2003; see HISTONE DEACETYLASE 1991-2002; see AMIDOHYDROLASES 1975-1990
History Note
2003; use AMIDOHYDROLASES 1975-1990
Entry Combination
antagonists & inhibitors:Histone Deacetylase Inhibitors
Date Established
1991/01/01
Date of Entry
1974/11/19
Revision Date
2009/07/06
Histone Deacetylases Preferred
Histone Deacetylase Complexes Narrower
Class I Histone Deacetylases Narrower
Class II Histone Deacetylases Narrower
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