MeSH Browser

MeSH Heading: Dihydroorotase
Tree Number(s): D08.811.277.087.280
Unique ID: D004080
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D004080
Scope Note: An enzyme that, in the course of pyrimidine biosynthesis, catalyzes ring closure by removal of water from N-carbamoylaspartate to yield dihydro-orotic acid. EC 3.5.2.3.
Entry Term(s): Carbamoylaspartic Dehydrase; Dihydro-Orotase; Dihydro-Orotate Amidohydrolase
Registry Numbers: EC 3.5.2.3
CAS Type 1 Name: (S)-Dihydroorotate amidohydrolase
Previous Indexing: Amidohydrolases (1966-1976); Orotic Acid (1966-1976)
Public MeSH Note: 95; was DIHYDRO-OROTASE 1977-94 (see under AMIDOHYDROLASES 1977-90)
Online Note: use DIHYDROOROTASE to search DIHYDRO-OROTASE 1977-94
History Note: 95; was DIHYDRO-OROTASE 1977-94 (see under AMIDOHYDROLASES 1977-90)
Date Established: 1991/01/01
Date of Entry: 1976/04/27
Revision Date: 2003/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0006391
Registry Numbers: EC 3.5.2.3
Scope Note: An enzyme that, in the course of pyrimidine biosynthesis, catalyzes ring closure by removal of water from N-carbamoylaspartate to yield dihydro-orotic acid. EC 3.5.2.3.
Terms: Dihydroorotase Preferred Term
Term UI T012373
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1977); Carbamoylaspartic Dehydrase
Term UI T012370
Date04/26/1976
LexicalTag NON
ThesaurusID UNK (19XX); Dihydro-Orotase
Term UI T012371
Date05/26/1994
LexicalTag NON
ThesaurusID NLM (1995); Dihydro-Orotate Amidohydrolase
Term UI T012372
Date04/26/1976
LexicalTag NON
ThesaurusID UNK (19XX)

Dihydroorotase MeSH Descriptor Data 2025