Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

Ku Autoantigen MeSH Descriptor Data 2025


MeSH Heading
Ku Autoantigen
Tree Number(s)
D08.811.277.040.025.159.155
D08.811.399.340.155
D12.776.157.687.493
D12.776.260.525
D12.776.660.625.625
D12.776.660.720.493
D23.050.290.625
Unique ID
D000072200
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000072200
Scope Note
An ATP-dependent DNA HELICASE that preferentially binds SINGLE-STRANDED DNA. It is a heterodimer consisting of an 80 kDa subunit (XRCC5) and 70 kDa subunit (XRCC6) that functions with DNA LIGASE IV in the repair of DOUBLE-STRANDED DNA BREAKS and V(D)J RECOMBINATION.
Entry Term(s)
G22P1 Antigen
Ku Antigen
Ku Autoantigen, 70 kDa
Ku Autoantigen, 80 kDa
Ku Heterodimer
Ku Protein
Ku70 Antigen
Ku80 Antigen
X-ray Repair Cross-Complementing Protein 5
X-ray Repair Cross-Complementing Protein 6
XRCC5 Protein
XRCC6 Protein
Registry Numbers
EC 4.2.99.-
0
EC 3.6.4.12
Related Numbers
EC 3.6.4.12
Public MeSH Note
2017; KU AUTOANTIGEN was indexed under DNA-BINDING PROTEINS and ANTIGENS, NUCLEAR 2003-2016; and under ANTIGENS, SURFACE 1986-1991 and NUCLEAR PROTEINS 1985-2003
History Note
2017 (1986)
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2017/05/24
Ku Autoantigen Preferred
Ku70 Antigen Narrower
Ku80 Antigen Narrower
page delivered in 0.197s