MeSH Browser

MeSH Heading: X-linked Nuclear Protein
Tree Number(s): D08.811.399.340.375
Unique ID: D000075924
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000075924
Scope Note: ATP-dependent DNA helicase that contains two N-terminal ZINC FINGERS and C-terminal ATP-binding and helicase domains. It functions in the regulation of gene transcription and CHROMATIN REMODELING. ATRX undergoes cell-cycle dependent phosphorylation, which causes it to translocate from the NUCLEAR MATRIX to CHROMATIN; thus, it may change its role from gene regulation during INTERPHASE to ensuring proper chromosome segregation at MITOSIS. Mutations in the ATRX gene are associated with cases of X-LINKED MENTAL RETARDATION co-morbid with ALPHA-THALASSEMIA (ATRX syndrome).
Entry Term(s): ATRX Protein; RAD54 Homolog Protein
Previous Indexing: DNA Helicases (1995-2017); Nuclear Proteins (1995-2017)
See Also: PHD Zinc Fingers
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000631684
Scope Note: ATP-dependent DNA helicase that contains two N-terminal ZINC FINGERS and C-terminal ATP-binding and helicase domains. It functions in the regulation of gene transcription and CHROMATIN REMODELING. ATRX undergoes cell-cycle dependent phosphorylation, which causes it to translocate from the NUCLEAR MATRIX to CHROMATIN; thus, it may change its role from gene regulation during INTERPHASE to ensuring proper chromosome segregation at MITOSIS. Mutations in the ATRX gene are associated with cases of X-LINKED MENTAL RETARDATION co-morbid with ALPHA-THALASSEMIA (ATRX syndrome).
Terms: X-linked Nuclear Protein Preferred Term
Term UI T000924512
Date05/15/2017
LexicalTag NON
ThesaurusID NLM (2018); ATRX Protein
Term UI T000924513
Date05/15/2017
LexicalTag ABX
ThesaurusID NLM (2018); RAD54 Homolog Protein
Term UI T000924514
Date05/15/2017
LexicalTag ABX
ThesaurusID NLM (2018)

X-linked Nuclear Protein MeSH Descriptor Data 2024