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X-linked Nuclear Protein MeSH Descriptor Data 2022


MeSH Heading
X-linked Nuclear Protein
Tree Number(s)
D08.811.399.340.375
Unique ID
D000075924
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000075924
Scope Note
ATP-dependent DNA helicase that contains two N-terminal ZINC FINGERS and C-terminal ATP-binding and helicase domains. It functions in the regulation of gene transcription and CHROMATIN REMODELING. ATRX undergoes cell-cycle dependent phosphorylation, which causes it to translocate from the NUCLEAR MATRIX to CHROMATIN; thus, it may change its role from gene regulation during INTERPHASE to ensuring proper chromosome segregation at MITOSIS. Mutations in the ATRX gene are associated with cases of X-LINKED MENTAL RETARDATION co-morbid with ALPHA-THALASSEMIA (ATRX syndrome).
Entry Term(s)
ATRX Protein
RAD54 Homolog Protein
Registry Number
EC 3.6.4.12
Previous Indexing
DNA Helicases (1995-2017)
Nuclear Proteins (1995-2017)
See Also
PHD Zinc Fingers
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/06/29
X-linked Nuclear Protein Preferred
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