MeSH Browser

MeSH Heading: RecQ Helicases
Tree Number(s): D08.811.277.040.025.159.249; D08.811.399.340.249
Unique ID: D053484
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053484
Scope Note: A family of structurally-related DNA helicases that play an essential role in the maintenance of genome integrity. RecQ helicases were originally discovered in E COLI and are highly conserved across both prokaryotic and eukaryotic organisms. Genetic mutations that result in loss of RecQ helicase activity gives rise to disorders that are associated with CANCER predisposition and premature aging.
Entry Term(s): ATP-Dependent DNA Helicase Q1; ATP-Dependent DNA Helicase Q4; ATP-Dependent DNA Helicase Q5; DNA Helicase Q1; DNA Helicase RecQL; DNA Helicase RecQL4; DNA Helicase, RecQ-like type 2; DNA-Dependent ATPase Q1; RECQL1 Helicase; RTS Helicase; RecQ Family of DNA Helicase; RecQ Family of DNA Helicases; RecQ Helicase; RecQ Protein; RecQ2 Helicase; RecQ3 Helicase; RecQ4 Helicase; RecQ5 Helicase; RecQ5L Helicase; RecQL Helicase; RecQL2 Helicase; RecQL3 Helicase; RecQL4 Helicase
Related Numbers: EC 3.6.4.12
See Also: Bloom Syndrome; Rothmund-Thomson Syndrome; Werner Syndrome
Public MeSH Note: 2007: RECQ HELICASES was indexed under ADENOSINE TRIPHOSPHATASES & DNA HELICASES 1990-2006; RECQ4 HELICASE was indexed under DNA HELICASES 2002-2006; DNA HELICASE RECQL was indexed under DNA HELICASES & ADENOSINE TRIPHOSPHATASES 1994-2006; RECQ5 HELICASE was indexed under DNA HELICASES 1999-2006
History Note: 2007(1990)
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Acid Anhydride Hydrolases [D08.811.277.040]
      - Adenosine Triphosphatases [D08.811.277.040.025]
        
        DNA Helicases [D08.811.277.040.025.159]
        
        DnaB Helicases [D08.811.277.040.025.159.124]
        
        Ku Autoantigen [D08.811.277.040.025.159.155]
        
        Minichromosome Maintenance Proteins [D08.811.277.040.025.159.186]
        
        RecQ Helicases [D08.811.277.040.025.159.249]
        
        Werner Syndrome Helicase [D08.811.277.040.025.159.249.500]
        
        Xeroderma Pigmentosum Group D Protein [D08.811.277.040.025.159.500]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Isomerases [D08.811.399]
    - DNA Helicases [D08.811.399.340]

RecQ Helicases Preferred

Concept UI: M0178844
Related Numbers: EC 3.6.4.12
Scope Note: A family of structurally-related DNA helicases that play an essential role in the maintenance of genome integrity. RecQ helicases were originally discovered in E COLI and are highly conserved across both prokaryotic and eukaryotic organisms. Genetic mutations that result in loss of RecQ helicase activity gives rise to disorders that are associated with CANCER predisposition and premature aging.
Terms: RecQ Helicases Preferred Term
Term UI T659320
Date11/21/2005
LexicalTag ABX
ThesaurusID NLM (2007); RecQ Helicase
Term UI T000997892
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); RecQ Family of DNA Helicase
Term UI T000997893
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); RecQ Family of DNA Helicases
Term UI T659324
Date11/21/2005
LexicalTag ABX
ThesaurusID NLM (2007); RecQ Protein
Term UI T208849
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2007)

RecQL Helicase Narrower

Concept UI: M0239601
Terms: RecQL Helicase Preferred Term
Term UI T269430
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2007); DNA Helicase RecQL
Term UI T269431
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2007); DNA-Dependent ATPase Q1
Term UI T269605
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2007); RECQL1 Helicase
Term UI T663836
Date01/05/2006
LexicalTag ABX
ThesaurusID NLM (2007); ATP-Dependent DNA Helicase Q1
Term UI T663835
Date01/05/2006
LexicalTag NON
ThesaurusID NLM (2007); DNA Helicase Q1
Term UI T269606
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2007)

RecQ5 Helicase Narrower

RecQ4 Helicase Narrower

Concept UI: M0414891
Terms: RecQ4 Helicase Preferred Term
Term UI T482602
Date02/19/2002
LexicalTag ABX
ThesaurusID NLM (2007); ATP-Dependent DNA Helicase Q4
Term UI T663832
Date01/05/2006
LexicalTag NON
ThesaurusID NLM (2007); DNA Helicase RecQL4
Term UI T427888
Date11/02/2000
LexicalTag ABX
ThesaurusID NLM (2007); RecQL4 Helicase
Term UI T663817
Date01/05/2006
LexicalTag ABX
ThesaurusID NLM (2007); RTS Helicase
Term UI T427887
Date11/02/2000
LexicalTag ABX
ThesaurusID NLM (2007)

RecQ2 Helicase Narrower

RecQ3 Helicase Narrower

RecQ Helicases MeSH Descriptor Data 2024