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Werner Syndrome Helicase MeSH Descriptor Data 2023


MeSH Heading
Werner Syndrome Helicase
Tree Number(s)
D08.811.277.040.025.159.249.500
D08.811.277.352.335.375.875
D08.811.277.352.365.290.500
D08.811.399.340.249.500
D12.776.157.687.750
D12.776.660.720.750
Unique ID
D000071657
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071657
Scope Note
A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.
Entry Term(s)
RECQ3 Protein
RECQL2 Protein
Werner Syndrome ATP-Dependent Helicase
Werner Syndrome RecQ-Like Helicase
Registry Number
EC 3.6.4.12
Previous Indexing
Exodeoxyribonucleases (1996-2016)
RecQ Helicases (2006-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2017/05/24
Werner Syndrome Helicase Preferred
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