- Concept UI
- M000615275
- Registry Numbers
- EC 3.6.4.12
- Scope Note
- A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.
- Terms
-
Werner Syndrome Helicase
Preferred Term
Term UI
T000896252
Date03/01/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
Werner Syndrome RecQ-Like Helicase
Term UI
T000896254
Date03/01/2016
LexicalTag
ABX
ThesaurusID
NLM (2017)
-
RECQ3 Protein
Term UI
T000896256
Date03/01/2016
LexicalTag
ABX
ThesaurusID
NLM (2017)
-
RECQL2 Protein
Term UI
T000896257
Date03/01/2016
LexicalTag
ABX
ThesaurusID
NLM (2017)
-
Werner Syndrome ATP-Dependent Helicase
Term UI
T000896253
Date03/01/2016
LexicalTag
NON
ThesaurusID
NLM (2017)