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Centromere Protein A MeSH Descriptor Data 2022


MeSH Heading
Centromere Protein A
Tree Number(s)
D12.776.157.687.173
D12.776.260.123
D12.776.660.235.100
D12.776.660.720.173
D12.776.664.235.100
D23.050.422.031
Unique ID
D000076247
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000076247
Scope Note
A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical role in recruiting kinetochore proteins and progression through MITOSIS, chromosome segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like AUTOIMMUNE DISEASES.
Entry Term(s)
CENP-A Protein
CENPA Protein
Centromere Autoantigens 17K
Centromere Protein 17K
Registry Number
0
Public MeSH Note
2018; CENTROMERE PROTEIN A was indexed under AUTOANTIGENS 1987-2017 and CHROMOSOMAL PROTEINS, NON-HISTONE 1990-2017; and under NUCLEOPROTEINS 1987-1989
History Note
2018 (1987)
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/06/29
Centromere Protein A Preferred
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