Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

Centromere Protein A MeSH Descriptor Data 2025


MeSH Heading
Centromere Protein A
Tree Number(s)
D12.776.157.687.173
D12.776.260.123
D12.776.660.235.100
D12.776.660.720.173
D12.776.664.235.100
D23.050.422.031
Unique ID
D000076247
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000076247
Scope Note
A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical role in recruiting kinetochore proteins and progression through MITOSIS, chromosome segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like AUTOIMMUNE DISEASES.
Entry Term(s)
CENP-A Protein
CENPA Protein
Centromere Autoantigens 17K
Centromere Protein 17K
Registry Numbers
0
Public MeSH Note
2018; CENTROMERE PROTEIN A was indexed under AUTOANTIGENS 1987-2017 and CHROMOSOMAL PROTEINS, NON-HISTONE 1990-2017; and under NUCLEOPROTEINS 1987-1989
History Note
2018 (1987)
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/06/29
Centromere Protein A Preferred
page delivered in 0.172s