- Concept UI
- M0301106
- Registry Numbers
- 0
- Scope Note
- A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.
- Terms
-
Apoptosis Inducing Factor
Preferred Term
Term UI
T331111
Date01/01/1955
LexicalTag
NON
ThesaurusID
NLM (2006)
-
AIF Apoptosis Regulatory Protein
Term UI
T629104
Date01/28/2005
LexicalTag
ABX
ThesaurusID
NLM (2006)
-
Apoptosis-Inducing Factor
Term UI
T331109
Date01/01/1955
LexicalTag
NON
ThesaurusID
NLM (2006)
-
Mitochondrial Apoptosis-Inducing Factor
Term UI
T331110
Date01/01/1955
LexicalTag
NON
ThesaurusID
NLM (2006)