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High-Temperature Requirement A Serine Peptidase 2 MeSH Descriptor Data 2022


MeSH Heading
High-Temperature Requirement A Serine Peptidase 2
Tree Number(s)
D08.811.277.656.300.760.431
D08.811.277.656.959.350.431
D12.776.476.075.429
D12.776.575.656
D12.776.637.625
Unique ID
D000074923
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000074923
Scope Note
A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE.
Entry Term(s)
HtrA Serine Peptidase 2
HtrA2 Protease
Omi Serine Protease
Serine Protease HTRA2
Serine Protease Omi
Registry Number
EC 3.4.21.108
See Also
PDZ Domains
Public MeSH Note
2018; HIGH-TEMPERATURE REQUIREMENT A SERINE PEPTIDASE 2 was indexed under SERINE ENDOPEPTIDASES and MITOCHONDRIAL PROTEINS 2000-2017
History Note
2018 (2000)
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2021/06/28
High-Temperature Requirement A Serine Peptidase 2 Preferred
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