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Proprotein Convertase 1 MeSH Descriptor Data 2022


MeSH Heading
Proprotein Convertase 1
Tree Number(s)
D08.811.277.656.300.760.640
D08.811.277.656.837.500
D08.811.277.656.959.350.640
Unique ID
D045664
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D045664
Scope Note
A CALCIUM-dependent endopeptidase that has specificity for cleavage at ARGININE that is near paired basic residues. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN; PRORENIN; proenkephalins; prodynorphin; prosomatostatin; and PROINSULIN.
Entry Term(s)
Neuroendocrine Convertase PC1
PC1 Endoprotease
PC1 Prohormone Convertase
PC3 Endoprotease
PC3 Prohormone Convertase
Prohormone Convertase 1
Prohormone Convertase 3
Prohormone Convertase, PC1
Proinsulin Convertase 1
Proprotein Convertase SPC3
Registry Number
EC 3.4.21.93
Previous Indexing
Aspartic Endopeptidases (1991-2003)
Public MeSH Note
2004; PC1 PROHORMONE CONVERTASE, NEUROENDOCRINE CONVERTASE PC1, PC3 ENDOPROTEASE & PROHORMONE CONVERTASE 1 were indexed under ASPARTIC ENDOPEPTIDASES 1991-2003; PC1 ENDOPROTEASE & PC3 PROHORMONE CONVERTASE were indexed under ASPARTIC ENDOPEPTIDASES 1993-2003; PROPROTEIN CONVERTASE SPC3 was indexed under ASPARTIC ENDOPEPTIDASES 2001-2003; PROINSULIN CONVERTASE 1 was indexed under ASPARTIC ENDOPEPTIDASES 2002-2003;
History Note
2004; for PC1 PROHORMONE CONVERTASE, NEUROENDOCRINE CONVERTASE PC1, PC3 ENDOPROTEASE, PROHORMONE CONVERTASE 1 use PROPROTEIN CONVERTASE (NM) 1991-2003; for PC1 ENDOPROTEASE & PC3 PROHORMONE CONVERTASE use PROPROTEIN CONVERTASE (NM) 1993-2003; for PROPROTEIN CONVERTASE SPC3 use PROPROTEIN CONVERTASE (NM) 2001-2003; for PROINSULIN CONVERTASE 1 use PROPROTEIN CONVERTASE (NM) 2002-2003
Date Established
2004/01/01
Date of Entry
2003/07/09
Revision Date
2009/07/06
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