MeSH Browser

MeSH Heading: Carboxypeptidase B2
Tree Number(s): D08.811.277.656.350.245.125; D08.811.277.656.350.555.225; D08.811.277.656.675.555.225; D08.811.277.656.837.092
Unique ID: D025901
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D025901
Scope Note: A carboxypeptidase that removes C-terminal lysine or arginine from peptides and proteins. Carboxypeptidase B2 (CPB2) is released into the circulation as a proenzyme which is activated by the THROMBIN-THROMBOMODULIN complex. Activated CPB2 is involved in modulating a variety of processes by cleaving and inactivating various circulating proteins and peptides that are its substrates including FIBRIN; KININS; and ANAPHYLATOXINS.
Entry Term(s): Arginine Carboxypeptidase; Carboxypeptidase B2, Plasma; Carboxypeptidase R; Carboxypeptidase U; Plasma Procarboxypeptidase B; Procarboxypeptidase U; Thrombin-Activatable Fibrinolysis Inhibitor; Thrombin-Activatable Fibrinolysis Inhibitor (TAFI)
Registry Number: EC 3.4.17.20
Previous Indexing: Carboxypeptidases (1979-2001); Lysine Carboxypeptidase (1994-2001)
Public MeSH Note: 2015; see CARBOXYPEPTIDASE U 2002-2014; CARBOXYPEPTIDASE U (NM) was indexed under CARBOXYPEPTIDASES 1994-2001; for ARGININE CARBOXYPEPTIDASE see LYSINE CARBOXYPEPTIDASE 1997-2001
History Note: 2015 (2002); use CARBOXYPEPTIDASE U (NM) 1994-2001 and LYSINE CARBOXYPEPTIDASE 1997-2001
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2014/06/06

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0376430
Registry Number: EC 3.4.17.20
Scope Note: A carboxypeptidase that removes C-terminal lysine or arginine from peptides and proteins. Carboxypeptidase B2 (CPB2) is released into the circulation as a proenzyme which is activated by the THROMBIN-THROMBOMODULIN complex. Activated CPB2 is involved in modulating a variety of processes by cleaving and inactivating various circulating proteins and peptides that are its substrates including FIBRIN; KININS; and ANAPHYLATOXINS.
Terms: Carboxypeptidase B2 Preferred Term
Term UI T852198
Date12/17/2013
LexicalTag NON
ThesaurusID NLM (2015); Arginine Carboxypeptidase
Term UI T003388
Date12/12/1995
LexicalTag NON
ThesaurusID NLM (1997); Carboxypeptidase R
Term UI T261610
LexicalTag NON
ThesaurusID NLM (2002); Thrombin-Activatable Fibrinolysis Inhibitor
Term UI T261612
LexicalTag NON
ThesaurusID NLM (2002); Thrombin-Activatable Fibrinolysis Inhibitor (TAFI)
Term UI T852199
Date12/17/2013
LexicalTag NON
ThesaurusID NLM (2015); Carboxypeptidase B2, Plasma
Term UI T852052
Date12/13/2013
LexicalTag NON
ThesaurusID NLM (2015); Carboxypeptidase U
Term UI T261613
LexicalTag NON
ThesaurusID NLM (2002)

Carboxypeptidase B2 MeSH Descriptor Data 2024