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Leucyl Aminopeptidase MeSH Descriptor Data 2023


MeSH Heading
Leucyl Aminopeptidase
Tree Number(s)
D08.811.277.656.350.100.511
D08.811.277.656.350.555.700
D08.811.277.656.675.555.700
Unique ID
D007931
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D007931
Scope Note
A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. This occurs in tissue cell cytosol, with high activity in the duodenum, liver, and kidney. The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide.
Entry Term(s)
Cytosol Aminopeptidase
L-Leucylnaphthylamidase
Leucine Aminopeptidase
Methoxyleucine Aminopeptidase
Peptidase S
Zinc-Manganese-Leucine Aminopeptidase
Registry Number
EC 3.4.11.1
Public MeSH Note
1999; see LEUCINE AMINOPEPTIDASE 1965-1998; PEPTIDASE S was indexed under AMINOPEPTIDASES 1979-1998; for LEUCYL-BETA-NAPTHYLAMIDASE see LEUCYL-BETA-NAPTHYLAMIDASE 1991-2009
History Note
1999(1965)
Date Established
1965/01/01
Date of Entry
1999/01/01
Revision Date
2016/06/28
Leucyl Aminopeptidase Preferred
Methoxyleucine Aminopeptidase Narrower
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