Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

Leucyl Aminopeptidase MeSH Descriptor Data 2025


MeSH Heading
Leucyl Aminopeptidase
Tree Number(s)
D08.811.277.656.350.100.511
D08.811.277.656.350.555.700
D08.811.277.656.675.555.700
Unique ID
D007931
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D007931
Scope Note
A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. This occurs in tissue cell cytosol, with high activity in the duodenum, liver, and kidney. The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide.
Entry Term(s)
Cytosol Aminopeptidase
L-Leucylnaphthylamidase
Leucine Aminopeptidase
Methoxyleucine Aminopeptidase
Peptidase S
Zinc-Manganese-Leucine Aminopeptidase
Registry Numbers
EC 3.4.11.1
0
Public MeSH Note
1999; see LEUCINE AMINOPEPTIDASE 1965-1998; PEPTIDASE S was indexed under AMINOPEPTIDASES 1979-1998; for LEUCYL-BETA-NAPTHYLAMIDASE see LEUCYL-BETA-NAPTHYLAMIDASE 1991-2009
History Note
1999(1965)
Date Established
1965/01/01
Date of Entry
1999/01/01
Revision Date
2016/06/28
Leucyl Aminopeptidase Preferred
Methoxyleucine Aminopeptidase Narrower
page delivered in 0.15s