MeSH Browser

MeSH Heading: Leucyl Aminopeptidase
Tree Number(s): D08.811.277.656.350.100.511; D08.811.277.656.350.555.700; D08.811.277.656.675.555.700
Unique ID: D007931
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007931
Scope Note: A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. This occurs in tissue cell cytosol, with high activity in the duodenum, liver, and kidney. The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide.
Entry Term(s): Cytosol Aminopeptidase; L-Leucylnaphthylamidase; Leucine Aminopeptidase; Methoxyleucine Aminopeptidase; Peptidase S; Zinc-Manganese-Leucine Aminopeptidase
Public MeSH Note: 1999; see LEUCINE AMINOPEPTIDASE 1965-1998; PEPTIDASE S was indexed under AMINOPEPTIDASES 1979-1998; for LEUCYL-BETA-NAPTHYLAMIDASE see LEUCYL-BETA-NAPTHYLAMIDASE 1991-2009
History Note: 1999(1965)
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/06/28

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0012373
Scope Note: A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. This occurs in tissue cell cytosol, with high activity in the duodenum, liver, and kidney. The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide.
Terms: Leucyl Aminopeptidase Preferred Term
Term UI T023624
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1965); Cytosol Aminopeptidase
Term UI T023619
Date12/30/1988
LexicalTag NON
ThesaurusID NLM (1990); L-Leucylnaphthylamidase
Term UI T023620
Date08/30/1982
LexicalTag NON
ThesaurusID UNK (19XX); Leucine Aminopeptidase
Term UI T023621
Date11/06/1997
LexicalTag NON
ThesaurusID NLM (1999); Zinc-Manganese-Leucine Aminopeptidase
Term UI T023622
Date11/29/1982
LexicalTag NON
ThesaurusID UNK (19XX); Peptidase S
Term UI T023623
Date12/08/1997
LexicalTag NON
ThesaurusID NLM (1999)

Leucyl Aminopeptidase MeSH Descriptor Data 2024