MeSH Browser

MeSH Heading: Pyroglutamyl-Peptidase I
Tree Number(s): D08.811.277.656.350.100.755
Unique ID: D011751
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D011751
Scope Note: An enzyme that catalyzes the release of a N-terminal pyroglutamyl group from a polypeptide provided the next residue is not proline. It is inhibited by thiol-blocking reagents and occurs in mammalian tissues, microorganisms, and plants. (From Enzyme Nomenclature, 1992) EC 3.4.19.3.
Entry Term(s): 5-Oxoprolyl-Peptidase; Pyroglutamate Aminopeptidase; Pyroglutamyl-Peptide Hydrolase; Pyrrolidonecarboxylate Peptidase; Pyrrolidonyl Peptidase
Previous Indexing: Aminopeptidases (1970-1974); Pyrrolidonecarboxylic Acid (1972-1974)
Public MeSH Note: 95: was 5-OXOPROLYL-PEPTIDASE 1991-94; was PYROGLUTAMATE AMINOPEPTIDASE see under AMINOPEPTIDASES 1975-90
Online Note: use PYROGLUTAMYL-PEPTIDASE I to search 5-OXOPROLYL-PEPTIDASE 1991-94 & PYROGLUTAMATE AMINOPEPTIDASE 1975-90
History Note: 95: was 5-OXOPROLYL-PEPTIDASE 1991-94; was PYROGLUTAMATE AMINOPEPTIDASE see under AMINOPEPTIDASES 1975-90
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2016/06/28

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0018270
Scope Note: An enzyme that catalyzes the release of a N-terminal pyroglutamyl group from a polypeptide provided the next residue is not proline. It is inhibited by thiol-blocking reagents and occurs in mammalian tissues, microorganisms, and plants. (From Enzyme Nomenclature, 1992) EC 3.4.19.3.
Terms: Pyroglutamyl-Peptidase I Preferred Term
Term UI T034741
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); 5-Oxoprolyl-Peptidase
Term UI T034745
Date11/18/1993
LexicalTag NON
ThesaurusID NLM (1995); Pyroglutamate Aminopeptidase
Term UI T034740
Date01/18/1990
LexicalTag NON
ThesaurusID NLM (1991); Pyroglutamyl-Peptide Hydrolase
Term UI T034742
Date11/13/1986
LexicalTag NON
ThesaurusID UNK (19XX); Pyrrolidonecarboxylate Peptidase
Term UI T034743
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); Pyrrolidonyl Peptidase
Term UI T034744
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX)

Pyroglutamyl-Peptidase I MeSH Descriptor Data 2024