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A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.
Entry Term(s)
Dibasic Processing Enzyme
Furin Protein
Paired Basic Amino Acid Cleaving Enzyme
SPC1 Proteinase
Registry Numbers
EC 3.4.21.75
Related Numbers
EC 3.4.21.75
Previous Indexing
Serine Endopeptidases (1989-1992)
Subtilisins (1993-2003)
Public MeSH Note
2004; FURIN was indexed under SUBTILISINS 1993-2003
A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.