MeSH Browser

MeSH Heading: von Willebrand Factor
Tree Number(s): D12.776.124.125.920; D23.119.985
Unique ID: D014841
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D014841
Annotation: / defic = VON WILLEBRAND DISEASE or specific type of Von Willebrand Disease
Scope Note: A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.
Entry Version: VWF
Entry Term(s): Factor VIII-Related Antigen; Factor VIIIR-Ag; Factor VIIIR-RCo; Plasma Factor VIII Complex; Ristocetin Cofactor; Ristocetin-Willebrand Factor; von Willebrand Protein
NLM Classification #: WH 310
Previous Indexing: Blood Coagulation Factors (1966-1974); Blood Platelets (1966-1974); von Willebrand's Disease (1966-1975)
See Also: Coagulants; von Willebrand Disease, Type 1; von Willebrand Disease, Type 2; von Willebrand Disease, Type 3; von Willebrand Diseases; Weibel-Palade Bodies
Public MeSH Note: 86; was see under BLOOD COAGULATION FACTORS 1976-85
Online Note: use FACTOR VIII & ANTIGENS to search FACTOR VIII RELATED ANTIGEN 1977-89
History Note: 86(76); was see under BLOOD COAGULATION FACTORS 1976-85; FACTOR VIII RELATED ANTIGEN, previously in the Supplementary Chemical File, was mapped to both FACTOR VIII & ANTIGENS 1977-89
Date Established: 1986/01/01
Date of Entry: 1975/07/25
Revision Date: 2009/07/06

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Blood Coagulation Factors [D12.776.124.125]

Biological Factors [D23]
- Blood Coagulation Factors [D23.119]

von Willebrand Factor Preferred

Concept UI: M0022850
Scope Note: A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.
Terms: von Willebrand Factor Preferred Term
Term UI T043381
Date01/01/1999
LexicalTag EPO
ThesaurusID NLM (1976); Factor VIIIR-Ag
Term UI T043384
Date04/20/1989
LexicalTag NON
ThesaurusID NLM (1990); Factor VIIIR-RCo
Term UI T043377
Date09/20/1984
LexicalTag NON
ThesaurusID UNK (19XX); Factor VIII-Related Antigen
Term UI T043376
Date04/20/1989
LexicalTag NON
ThesaurusID NLM (1990); Ristocetin-Willebrand Factor
Term UI T043380
Date04/23/1981
LexicalTag EPO
ThesaurusID UNK (19XX); von Willebrand Protein
Term UI T043382
Date01/03/1985
LexicalTag EPO
ThesaurusID UNK (19XX); Ristocetin Cofactor
Term UI T043379
Date04/23/1981
LexicalTag NON
ThesaurusID UNK (19XX)

Plasma Factor VIII Complex Broader

von Willebrand Factor MeSH Descriptor Data 2024