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Kininogens MeSH Descriptor Data 2022


MeSH Heading
Kininogens
Tree Number(s)
D12.644.276.812.654
D12.776.124.125.635
D12.776.467.812.654
D12.776.811.420
D23.119.630
D23.469.050.375.425
D23.529.812.654
Unique ID
D007704
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D007704
Annotation
cysteine proteinase inhib; /‌drug eff /‌physiol permitted
Scope Note
Endogenous peptides present in most body fluids. Certain enzymes convert them to active KININS which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by plasma kallikrein to produce BRADYKININ. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by tissue kallikrein to produce KALLIDIN.
Entry Term(s)
Cystatins, Kininogen
Kininogen
Prekinins
Prokinins
T-Kininogen
Thiostatin
Pharm Action
Cysteine Proteinase Inhibitors
Registry Number
0
Previous Indexing
Kinins (1966-1971)
Proteins (1966-1971)
Public MeSH Note
74
History Note
74(72)
Date Established
1974/01/01
Date of Entry
1999/01/01
Revision Date
2006/07/05
Kininogens Preferred
T-Kininogen Narrower
Thiostatin Narrower
Kininogen Narrower
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