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Progranulins MeSH Descriptor Data 2022


MeSH Heading
Progranulins
Tree Number(s)
D06.472.699.682
D12.644.276.917
D12.776.467.917
D12.776.811.703
D23.529.917
Unique ID
D000077153
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000077153
Scope Note
Cysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain granulin-repeats separated by linker sequences that are cleaved by a variety of proteases to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide. Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is linked to neurodegenerative diseases including FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE.
Entry Term(s)
Acrogranin
Granulin Precursor
Granulin Precursor Protein
PC Cell-Derived Growth Factor
Proepithelin
Progranulin
Registry Number
0
Related Numbers
134710-81-9
Previous Indexing
Intercellular Signaling Peptides and Proteins (1999-2018)
Public MeSH Note
2019; GRANULIN PRECURSOR PROTEIN was indexed under INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS 2004-2018 and VIRAL PROTEINS1992-2003
History Note
2019
Date Established
2019/01/01
Date of Entry
2018/07/09
Revision Date
2019/07/05
Progranulins Preferred
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