MeSH Browser

MeSH Heading: Semaphorins
Tree Number(s): D12.644.276.923; D12.776.467.923; D23.529.923
Unique ID: D039961
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D039961
Scope Note: A family of proteins that mediate AXONAL GUIDANCE. Semaphorins act as repulsive cues for neuronal GROWTH CONES and bind to receptors on their filopodia. At least 20 different molecules have been described and divided into eight classes based on domain organization and species of origin. Classes 1 and 2 are invertebrate, classes 3-7 are vertebrate, and class V are viral. Semaphorins may be secreted (classes 2, 3, and V), transmembrane (classes 1, 4, 5, and 6), or membrane-anchored (class 7). All semaphorins possess a common 500-amino acid extracellular domain which is critical for receptor binding and specificity, and is also found in plexins and scatter factor receptors. Their C termini are class-specific and may contain additional sequence motifs.
Entry Term(s): Class 1 Semaphorins; Class 2 Semaphorins; Class 3 Semaphorins; Class 4 Semaphorins; Class 5 Semaphorins; Class 6 Semaphorins; Class 7 Semaphorins; Class V Semaphorins; Sema 1; Semaphorin; Semaphorin-1; Semaphorin-2; Semaphorin-3; Semaphorin-4; Semaphorin-5; Semaphorin-6; Semaphorin-7; Semaphorin-V
Registry Numbers: 0
Public MeSH Note: 2003; SEMA 1 & SEMAPHORIN-1 was indexed under CELL ADHESION MOLECULES, NEURONAL 1994-2002
History Note: 2003; for SEMA 1 & SEMAPHORIN-1 use SEMAPHORIN 1A, GRASSHOPPER (NM) 1994-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2016/02/26

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adverse effects (AE)

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Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]

Semaphorins Preferred

Class 2 Semaphorins Narrower

Class 3 Semaphorins Narrower

Class 4 Semaphorins Narrower

Class 5 Semaphorins Narrower

Class 6 Semaphorins Narrower

Class 7 Semaphorins Narrower

Class 1 Semaphorins Narrower

Concept UI: M0209551
Registry Numbers: 0
Scope Note: Transmembrane proteins involved in axonal guidance of peripheral neurons in the developing CNS of invertebrates. Semaphorin-1 refers to the class of SEMAPHORINS with an extracellular sema domain and a short cytoplasmic domain. Sema-1 was first identified in grasshopper as fasciclin IV, and has since been described in Drosophila and C. elegans. Two distinct members of this class of semaphorins exist: SEMA-1a (the original sema-1) and SEMA-1b, a homologous protein isolated from Drosophila which may be more important for neuronal differentiation than migration.
Terms: Class 1 Semaphorins Preferred Term
Term UI T491124
Date04/26/2002
LexicalTag NON
ThesaurusID NLM (2003); Sema 1
Term UI T239555
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Semaphorin-1
Term UI T239556
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003)

Class V Semaphorins Narrower

Semaphorins MeSH Descriptor Data 2025