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Agouti Signaling Protein MeSH Descriptor Data 2022


MeSH Heading
Agouti Signaling Protein
Tree Number(s)
D12.644.276.049
D12.776.467.049
D23.529.049
Unique ID
D054366
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D054366
Scope Note
A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in MELANOCYTES. Agouti protein antagonizes the signaling of MELANOCORTIN RECEPTORS and has wide distribution including ADIPOSE TISSUE; GONADS; and HEART. Its overexpression in agouti mice results in uniform yellow coat color, OBESITY, and metabolic defects similar to type II diabetes in humans.
Entry Term(s)
ASIP Protein
Agouti Protein
Agouti Switch Protein
Registry Number
0
Previous Indexing
Intercellular Signaling Peptides and Proteins (1994-2007)
Public MeSH Note
2008; AGOUTI PROTEIN was indexed under INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS 1993-2007
History Note
2008 (1993)
Date Established
2008/01/01
Date of Entry
2007/07/09
Agouti Signaling Protein Preferred
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