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The prototypical and most well-studied member of the semaphorin family. Semaphorin-3A is an axon-repulsive guidance cue for migrating neurons in the developing nervous system. It has so far been found only in vertebrates, and binds to NEUROPILIN-1/plexin complex receptors on growth cones. Like other class 3 semaphorins, it is a secreted protein.
Entry Term(s)
Collapsin
Collapsin-1
Collapsing Factor
Sem D
Sema3A
Semaphorin 3A
Semaphorin D
Registry Numbers
0
Previous Indexing
Glycoproteins (1993-2002)
Public MeSH Note
2003; COLLAPSIN (now SEMAPHORIN 3A) was indexed under GLYCOPROTEINS 1993-2002
The prototypical and most well-studied member of the semaphorin family. Semaphorin-3A is an axon-repulsive guidance cue for migrating neurons in the developing nervous system. It has so far been found only in vertebrates, and binds to NEUROPILIN-1/plexin complex receptors on growth cones. Like other class 3 semaphorins, it is a secreted protein.