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Neuropilin-1 MeSH Descriptor Data 2024

MeSH Heading
Tree Number(s)
Unique ID
RDF Unique Identifier
Scope Note
A dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and AXONAL GUIDANCE. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS; their binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.
Entry Term(s)
A5 Antigen
NRP1 Protein
Npn-1 Protein
Sema III Receptor
Semaphorin III Receptor
Registry Number
Previous Indexing
Nerve Tissue Proteins (1991-2002)
Public MeSH Note
2003; A5 ANTIGEN (now NEUROPILIN-1) was indexed under NERVE TISSUE PROTEINS 1991-2002
History Note
2003; use NEUROPILIN-1 (NM) 1991-2002
Date Established
Date of Entry
Revision Date
Neuropilin-1 Preferred
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