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Neuropilin-1 MeSH Descriptor Data 2022


MeSH Heading
Neuropilin-1
Tree Number(s)
D12.776.543.750.590.500
Unique ID
D039942
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D039942
Scope Note
A dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and AXONAL GUIDANCE. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS; their binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.
Entry Term(s)
A5 Antigen
NRP1 Protein
Npn-1 Protein
Sema III Receptor
Semaphorin III Receptor
Registry Number
144713-63-3
Previous Indexing
Nerve Tissue Proteins (1991-2002)
Public MeSH Note
2003; A5 ANTIGEN (now NEUROPILIN-1) was indexed under NERVE TISSUE PROTEINS 1991-2002
History Note
2003; use NEUROPILIN-1 (NM) 1991-2002
Date Established
2003/01/01
Date of Entry
2002/07/03
Revision Date
2016/07/05
Neuropilin-1 Preferred
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