MeSH Browser

MeSH Heading: Neuropilin-1
Tree Number(s): D12.776.543.750.590.500
Unique ID: D039942
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D039942
Scope Note: A dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and AXONAL GUIDANCE. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS; their binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.
Entry Term(s): A5 Antigen; NRP1 Protein; Npn-1 Protein; Sema III Receptor; Semaphorin III Receptor
Previous Indexing: Nerve Tissue Proteins (1991-2002)
Public MeSH Note: 2003; A5 ANTIGEN (now NEUROPILIN-1) was indexed under NERVE TISSUE PROTEINS 1991-2002
History Note: 2003; use NEUROPILIN-1 (NM) 1991-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2016/07/05

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Concept UI: M0191842
Scope Note: A dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and AXONAL GUIDANCE. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS; their binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.
Terms: Neuropilin-1 Preferred Term
Term UI T221844
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Npn-1 Protein
Term UI T221840
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2003); Sema III Receptor
Term UI T221842
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2003); Semaphorin III Receptor
Term UI T221846
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); A5 Antigen
Term UI T221847
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); NRP1 Protein
Term UI T435156
Date02/03/2001
LexicalTag ACX
ThesaurusID NLM (2003)

Neuropilin-1 MeSH Descriptor Data 2024