MeSH Browser

MeSH Heading: Angiotensinogen
Tree Number(s): D12.644.456.073.070; D12.644.861.020; D12.776.811.070; D12.776.872.020
Unique ID: D000808
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000808
Scope Note: An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM.
Entry Term(s): Hypertensinogen; Proangiotensin; Renin Substrate Tetradecapeptide; Renin-Substrate; SERPINA8; Serpin A8
Pharm Action: Serine Proteinase Inhibitors
CAS Type 1 Name: Angiotensinogen (protein renin substrate)
NLM Classification #: QU 68
Previous Indexing: Alpha Globulins (1968-1974); Angiotensin II (1968-1974); Protein Precursors (1971-1974)
Public MeSH Note: 87; was see under ANGIOTENSINS 1975-86
History Note: 87(75); was see under ANGIOTENSINS 1975-86
Date Established: 1987/01/01
Date of Entry: 1974/11/19
Revision Date: 2020/06/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0001208
Scope Note: An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM.
Terms: Angiotensinogen Preferred Term
Term UI T002404
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Hypertensinogen
Term UI T002405
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); Proangiotensin
Term UI T002406
Date02/10/1981
LexicalTag NON
ThesaurusID UNK (19XX); Renin-Substrate
Term UI T002407
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); Serpin A8
Term UI T734759
Date02/09/2009
LexicalTag NON
ThesaurusID NLM (2010); SERPINA8
Term UI T001079484
Date04/29/2020
LexicalTag NON
ThesaurusID NLM (2021)

Angiotensinogen MeSH Descriptor Data 2024