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Peptidyl-Dipeptidase A MeSH Descriptor Data 2022


MeSH Heading
Peptidyl-Dipeptidase A
Tree Number(s)
D08.811.277.656.350.350.687
Unique ID
D007703
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D007703
Scope Note
A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of ANGIOTENSIN I to ANGIOTENSIN II, with increase in vasoconstrictor activity, but no action on angiotensin II. It is also able to inactivate BRADYKININ, a potent vasodilator; and has a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. (From https://www.uniprot.org April 15, 2020).
Entry Term(s)
ACE1 Angiotensin-Converting Enzyme 1
ACE1 Protein
Angiotensin Converting Enzyme
Angiotensin Converting Enzyme 1
Angiotensin I-Converting Enzyme
Antigens, CD143
CD143 Antigens
Carboxycathepsin
Dipeptidyl Carboxypeptidase I
Dipeptidyl Peptidase A
Kininase A
Kininase II
Peptidase P
Registry Number
EC 3.4.15.1
Previous Indexing
Peptide Peptidohydrolases (1966-1972)
Public MeSH Note
1994; see KININASE II 1974-93; for TONIN see KININASE II 1984-93
History Note
1994; for TONIN use KININASE II 1984-93
Entry Combination
antagonists & inhibitors:Angiotensin-Converting Enzyme Inhibitors
Date Established
1974/01/01
Date of Entry
1999/01/01
Revision Date
2021/06/30
Peptidyl-Dipeptidase A Preferred
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