MeSH Browser

MeSH Heading: Kininogen, High-Molecular-Weight
Tree Number(s): D12.644.276.812.654.350; D12.776.124.125.635.480; D12.776.467.812.654.350; D12.776.811.420.350; D23.119.630.480; D23.469.050.375.425.350; D23.529.812.654.350
Unique ID: D019679
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019679
Scope Note: A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)
Entry Version: KININOGEN HMW
Entry Term(s): Fitzgerald Factor; HMWK; High Molecular Weight Kininogen; High Molecular Weight Kininogens; High-Molecular-Weight Kininogen; High-Molecular-Weight Kininogens; Kininogens, High Molecular Weight
Previous Indexing: Kininogens (1974-1997)
Public MeSH Note: 98; see KININOGENS 1989-97
History Note: 98; use KININOGENS 1989-97
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2006/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0029210
Scope Note: A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)
Terms: Kininogen, High-Molecular-Weight Preferred Term
Term UI T058516
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1998); High-Molecular-Weight Kininogen
Term UI T058515
Date10/25/1996
LexicalTag NON
ThesaurusID NLM (1998); HMWK
Term UI T058517
Date10/24/1996
LexicalTag ABB
ThesaurusID NLM (1998); Fitzgerald Factor
Term UI T058510
Date10/24/1996
LexicalTag EPO
ThesaurusID NLM (1998); High Molecular Weight Kininogens
Term UI T058511
Date10/25/1996
LexicalTag NON
ThesaurusID NLM (1998); Kininogens, High Molecular Weight
Term UI T058512
Date10/24/1996
LexicalTag NON
ThesaurusID NLM (1998); High-Molecular-Weight Kininogens
Term UI T058514
Date10/25/1996
LexicalTag NON
ThesaurusID NLM (1998); High Molecular Weight Kininogen
Term UI T058513
Date10/25/1996
LexicalTag NON
ThesaurusID NLM (1998)

Kininogen, High-Molecular-Weight MeSH Descriptor Data 2024