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Tissue Plasminogen Activator MeSH Descriptor Data 2022


MeSH Heading
Tissue Plasminogen Activator
Tree Number(s)
D08.811.277.656.300.760.875
D08.811.277.656.959.350.875
D12.776.124.125.662.768
D23.119.970
Unique ID
D010959
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D010959
Scope Note
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
Entry Term(s)
Actilyse
Activase
Alteplase
Lysatec rt-PA
Plasminogen Activator, Tissue-Type
T-Plasminogen Activator
TTPA
Tisokinase
Tissue Activator D-44
Tissue-Type Plasminogen Activator
Pharm Action
Fibrinolytic Agents
Registry Number
EC 3.4.21.68
Related Numbers
105857-23-6
Previous Indexing
Enzyme Activation (1974-1975)
Peptide Hydrolases (1975)
Plasminogen Activators (1976-1985)
Public MeSH Note
98; see ALTEPLASE 1992-97; see PLASMINOGEN ACTIVATOR, TISSUE-TYPE 1986-91
History Note
98(86)
Date Established
1986/01/01
Date of Entry
1985/06/12
Revision Date
2016/07/01
Tissue Plasminogen Activator Preferred
Activase Narrower
Actilyse Narrower
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