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High-Temperature Requirement A Serine Peptidase 1 MeSH Descriptor Data 2022


MeSH Heading
High-Temperature Requirement A Serine Peptidase 1
Tree Number(s)
D08.811.277.656.300.760.420
D08.811.277.656.959.350.420
Unique ID
D000074289
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000074289
Scope Note
A secreted serine protease that contains a Kazal domain-like region and a C-terminal PDZ domain. It has a broad range of targets that include EXTRACELLULAR MATRIX PROTEINS; PROTEOGLYCANS; and INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS. Mutations in the HTRA1 gene are associated with AGE-RELATED MACULAR DEGENERATION 7 and Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL).
Entry Term(s)
Serine Protease HTRA1
Registry Number
EC 3.4.21.-
Previous Indexing
Serine Endopeptidases (2003-2017)
See Also
Kazal Motifs
PDZ Domains
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/06/01
High-Temperature Requirement A Serine Peptidase 1 Preferred
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