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Mannose-Binding Protein-Associated Serine Proteases MeSH Descriptor Data 2022


MeSH Heading
Mannose-Binding Protein-Associated Serine Proteases
Tree Number(s)
D08.811.277.656.300.760.501
D08.811.277.656.959.350.501
D12.776.124.486.274.045.387.875
Unique ID
D050606
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D050606
Annotation
see SCR for organism-specific terms
Scope Note
Serum serine proteases which participate in COMPLEMENT ACTIVATION. They are activated when complexed with the MANNOSE-BINDING LECTIN, therefore also known as Mannose-binding protein-Associated Serine Proteases (MASPs). They cleave COMPLEMENT C4 and COMPLEMENT C2 to form C4b2a, the CLASSICAL PATHWAY C3 CONVERTASE.
Entry Term(s)
MASP
MASP Proteases
MASP-Related Protein
MASPs
MBL-Associated Serine Proteases
MBP-Associated Serine Protease
MBP-Associated Serine Protease-Related Protein
Mannan-Binding Lectin Serine Proteases
Mannose-Binding Protein-Associated Serine Protease
Pharm Action
Immunologic Factors
Registry Number
EC 3.4.21.-
Previous Indexing
Mannose-Binding Lectins (1992-2005)
Serine Endopeptidases (1992-2005)
Public MeSH Note
2006; MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES was indexed under SERINE ENDOPEPTIDASES 1994-2005
History Note
2006 (1994)
Date Established
2006/01/01
Date of Entry
2005/06/30
Revision Date
2020/06/17
Mannose-Binding Protein-Associated Serine Proteases Preferred
MASP-Related Protein Related
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