NLM Logo

Ferrochelatase MeSH Descriptor Data 2022


MeSH Heading
Ferrochelatase
Tree Number(s)
D08.811.520.500
D12.776.157.427.374.375.957
D12.776.556.579.374.375.617
D12.776.575.562
Unique ID
D005294
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D005294
Scope Note
A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.
Entry Term(s)
Heme Synthetase
Porphyrin-Metal Chelatase
Protoheme Ferro-Lyase
Zinc Chelatase
Registry Number
EC 4.99.1.1
Related Numbers
9012-93-5
EC 4.99.1.1
CAS Type 1 Name
Protoheme ferro-lyase
Previous Indexing
Iron (1966-1976)
Lyases (1966-1976)
Porphyrins (1966-1976)
Protoporphyrins (1975-1976)
Public MeSH Note
1991; see LYASES 1977-1990
History Note
1991(1977); use LYASES 1977-1990
Entry Combination
deficiency:Protoporphyria, Erythropoietic
Date Established
1991/01/01
Date of Entry
1976/04/27
Revision Date
2011/06/24
Ferrochelatase Preferred
Zinc Chelatase Narrower
page delivered in 0.157s