MeSH Browser

MeSH Heading: Iron Regulatory Protein 2
Tree Number(s): D08.811.520.241.300.050.750; D12.776.157.427.374.375.961; D12.776.157.725.437; D12.776.494.750; D12.776.556.579.374.375.962; D12.776.664.962.437
Unique ID: D035942
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D035942
Scope Note: A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its rate of degradation is increased in the presence of IRON.
Entry Term(s): IRE-BP2; IREB2 Protein; IRP-2 RNA-binding protein; IRP2 Protein; Iron-Responsive-Element Binding Protein 2
Registry Numbers: EC 4.2.1.3
Previous Indexing: Iron-Sulfur Proteins (1995-2002); Ribonucleoproteins (1995-2002)
Public MeSH Note: 2003; IRON REGULATORY PROTEIN 2, IRE-BP2 & IRP-2 RNA-BINDING PROTEIN were indexed under RNA-BINDING PROTEINS & IRON-SULFUR PROTEINS 1995-2002
History Note: 2003; for IRON REGULATORY PROTEIN 2, IRE-BP2 & IRP-2 RNA-BINDING PROTEIN use IRON-REGULATORY PROTEINS (NM) 1995-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2006/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0175238
Registry Numbers: EC 4.2.1.3
Scope Note: A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its rate of degradation is increased in the presence of IRON.
Terms: Iron Regulatory Protein 2 Preferred Term
Term UI T205243
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); IRE-BP2
Term UI T205235
Date01/01/1955
LexicalTag ACR
ThesaurusID NLM (2003); IRP-2 RNA-binding protein
Term UI T205238
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2003); IRP2 Protein
Term UI T475074
Date12/27/2001
LexicalTag ACX
ThesaurusID NLM (2003); Iron-Responsive-Element Binding Protein 2
Term UI T475077
Date12/27/2001
LexicalTag NON
ThesaurusID NLM (2003); IREB2 Protein
Term UI T475078
Date12/27/2001
LexicalTag NON
ThesaurusID NLM (2003)

Iron Regulatory Protein 2 MeSH Descriptor Data 2025