MeSH Browser

MeSH Heading: Frataxin
Tree Number(s): D12.776.157.427.374.375.959; D12.776.556.579.374.375.789; D12.776.575.609
Unique ID: D000096923
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000096923
Scope Note: A protein involved in the transfer of iron and sulfur to iron-sulfur cluster (ISC) assembly complex for de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. Deficiency leads to the neurodegenerative disease FRIEDREICH ATAXIA.
Entry Term(s): FXN Frataxin; Frataxin Protein; Friedreich Ataxia Protein
Public MeSH Note: 2024; FRATAXIN was indexed under IRON-BINDING PROTEINS 1996-2023
History Note: 2024 (1996)
Date Established: 2024/01/01
Date of Entry: 2023/07/26
Revision Date: 2023/05/17

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000762767
Scope Note: A protein involved in the transfer of iron and sulfur to iron-sulfur cluster (ISC) assembly complex for de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. Deficiency leads to the neurodegenerative disease FRIEDREICH ATAXIA.
Terms: Frataxin Preferred Term
Term UI T001132981
Date02/16/2023
LexicalTag NON
ThesaurusID NLM (2024); Frataxin Protein
Term UI T001132984
Date02/16/2023
LexicalTag NON
ThesaurusID NLM (2024); Friedreich Ataxia Protein
Term UI T001132982
Date02/16/2023
LexicalTag NON
ThesaurusID NLM (2024); FXN Frataxin
Term UI T001132983
Date02/16/2023
LexicalTag NON
ThesaurusID NLM (2024)

Frataxin MeSH Descriptor Data 2024