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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 MeSH Descriptor Data 2022


MeSH Heading
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Tree Number(s)
D08.811.913.696.620.682.700.534
D12.776.476.563.534
D12.776.637.750
Unique ID
D000071158
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071158
Scope Note
A serine/threonine protein kinase with GTPase activity that contains 12 LEUCINE-rich repeats in its central region and 7 WD repeats C-terminal to its kinase and GTPase domains. It localizes to TRANSPORT VESICLES; the OUTER MITOCHONDRIAL MEMBRANE; and the GOLGI APPARATUS. It functions in PROTEIN TRANSPORT; regulates neuron morphology in the central nervous system, and also functions in the trafficking of SYNAPTIC VESICLES. Mutations in the LRRK2 gene have been identified in autosomal dominant cases of PARKINSON DISEASE (PARK8).
Entry Term(s)
Dardarin Protein
LRRK2 Protein
PARK8 Protein
Registry Number
EC 2.7.11.1
Previous Indexing
Protein-Serine-Threonine Kinases (2005-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2021/05/21
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Preferred
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