MeSH Browser

MeSH Heading: p21-Activated Kinases
Tree Number(s): D08.811.913.696.620.682.700.596; D12.776.476.563.596
Unique ID: D054462
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054462
Scope Note: A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEINS such as RAC GTP-BINDING PROTEINS and CDC42 GTP-BINDING PROTEIN. They are intracellular signaling kinases that play a role the regulation of cytoskeletal organization.
Entry Term(s): Oligophrenin-3; PAK Kinase; PAK Kinases; PAK-1 Kinase; PAK-2 Kinase; PAK1 Kinase; PAK2 Kinase; PAK3 Kinase; PAK65; Serine-Threonine-Protein Kinase PAK 1; Serine-Threonine-Protein Kinase PAK 3; alpha p21-Activated Kinase; alpha-PAK; beta p21-Activated Kinase; beta-PAK; gamma-PAK; p21-Activated Kinase; p21-Activated Kinase 1; p21-Activated Kinase 2; p21-Activated Kinase 3; p65(PAK); p65PAK Protein
Registry Number: EC 2.7.11.1
Related Numbers: EC 2.7.11.1
Previous Indexing: Protein-Serine-Threonine Kinases (1995-2007)
Public MeSH Note: 2008; P21-ACTIVATED KINASE 1, P21-ACTIVATED KINASE 2 & P21-ACTIVATED KINASE 3 were indexed under PROTEIN-SERINE-THREONINE KINASES 1995-2007
History Note: 2008
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2021/06/28

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        Activin Receptors [D08.811.913.696.620.682.700.062]
        
        AMP-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.074]
        
        AMP-Activated Protein Kinases [D08.811.913.696.620.682.700.085]
        
        Ataxia Telangiectasia Mutated Proteins [D08.811.913.696.620.682.700.097]
        
        Aurora Kinases [D08.811.913.696.620.682.700.103]
        
        Autophagy-Related Protein-1 Homolog [D08.811.913.696.620.682.700.108]
        
        Bone Morphogenetic Protein Receptors [D08.811.913.696.620.682.700.109]
        
        Calcium-Calmodulin-Dependent Protein Kinases [D08.811.913.696.620.682.700.125]
        
        Casein Kinases [D08.811.913.696.620.682.700.140]
        
        Checkpoint Kinase 1 [D08.811.913.696.620.682.700.143]
        
        Checkpoint Kinase 2 [D08.811.913.696.620.682.700.145]
        
        Cyclic Nucleotide-Regulated Protein Kinases [D08.811.913.696.620.682.700.150]
        
        DNA-Activated Protein Kinase [D08.811.913.696.620.682.700.250]
        
        Doublecortin-Like Kinases [D08.811.913.696.620.682.700.275]
        
        Dyrk Kinases [D08.811.913.696.620.682.700.288]
        
        eIF-2 Kinase [D08.811.913.696.620.682.700.300]
        
        G-Protein-Coupled Receptor Kinases [D08.811.913.696.620.682.700.364]
        
        Germinal Center Kinases [D08.811.913.696.620.682.700.397]
        
        Glycogen Synthase Kinases [D08.811.913.696.620.682.700.429]
        
        I-kappa B Kinase [D08.811.913.696.620.682.700.494]
        
        Interleukin-1 Receptor-Associated Kinases [D08.811.913.696.620.682.700.526]
        
        Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 [D08.811.913.696.620.682.700.534]
        
        Lim Kinases [D08.811.913.696.620.682.700.542]
        
        MAP Kinase Kinase Kinases [D08.811.913.696.620.682.700.559]
        
        Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.565]
        
        Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567]
        
        Myotonin-Protein Kinase [D08.811.913.696.620.682.700.576]
        
        NF-kappaB-Inducing Kinase [D08.811.913.696.620.682.700.579]
        
        NIMA-Related Kinases [D08.811.913.696.620.682.700.581]
        
        Oncogene Protein v-akt [D08.811.913.696.620.682.700.586]
        
        p21-Activated Kinases [D08.811.913.696.620.682.700.596]
        
        Phytochrome A [D08.811.913.696.620.682.700.606]
        
        Polo-like Kinases [D08.811.913.696.620.682.700.616]
        
        Positive Transcriptional Elongation Factor B [D08.811.913.696.620.682.700.626]
        
        Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
        
        Protein Kinase C [D08.811.913.696.620.682.700.725]
        
        3-Phosphoinositide-Dependent Protein Kinases [D08.811.913.696.620.682.700.745]
        
        Protein Kinase D2 [D08.811.913.696.620.682.700.750]
        
        Proto-Oncogene Proteins c-akt [D08.811.913.696.620.682.700.755]
        
        Proto-Oncogene Proteins c-bcr [D08.811.913.696.620.682.700.759]
        
        Proto-Oncogene Proteins c-pim-1 [D08.811.913.696.620.682.700.776]
        
        Pyruvate Dehydrogenase Acetyl-Transferring Kinase [D08.811.913.696.620.682.700.783]
        
        Receptor, Transforming Growth Factor-beta Type I [D08.811.913.696.620.682.700.789]
        
        Receptor, Transforming Growth Factor-beta Type II [D08.811.913.696.620.682.700.795]
        
        Receptor-Interacting Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700.801]
        
        rho-Associated Kinases [D08.811.913.696.620.682.700.814]
        
        Ribosomal Protein S6 Kinases [D08.811.913.696.620.682.700.862]
        
        Serine-Threonine Kinase 3 [D08.811.913.696.620.682.700.897]
        
        TOR Serine-Threonine Kinases [D08.811.913.696.620.682.700.931]
        
        Vacuolar Sorting Protein VPS15 [D08.811.913.696.620.682.700.965]
        
        WNK Lysine-Deficient Protein Kinase 1 [D08.811.913.696.620.682.700.982]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]

p21-Activated Kinases Preferred

Concept UI: M0505237
Registry Number: EC 2.7.11.1
Related Numbers: EC 2.7.11.1
Scope Note: A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEINS such as RAC GTP-BINDING PROTEINS and CDC42 GTP-BINDING PROTEIN. They are intracellular signaling kinases that play a role the regulation of cytoskeletal organization.
Terms: p21-Activated Kinases Preferred Term
Term UI T688767
Date01/04/2007
LexicalTag NON
ThesaurusID NLM (2008); PAK Kinases
Term UI T688768
Date01/04/2007
LexicalTag ABX
ThesaurusID NLM (2008); p21-Activated Kinase
Term UI T000997448
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); PAK Kinase
Term UI T000997449
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021)

p21-Activated Kinase 2 Narrower

Concept UI: M0249380
Registry Number: EC 2.7.11.1
Terms: p21-Activated Kinase 2 Preferred Term
Term UI T279384
LexicalTag NON
ThesaurusID NLM (2008); p65(PAK)
Term UI T257731
LexicalTag ABB
ThesaurusID NLM (2008); p65PAK Protein
Term UI T257732
LexicalTag ABX
ThesaurusID NLM (2008); PAK-2 Kinase
Term UI T402839
Date12/15/1999
LexicalTag ABX
ThesaurusID NLM (2008); PAK2 Kinase
Term UI T279385
LexicalTag ABX
ThesaurusID NLM (2008); PAK65
Term UI T059244
Date02/14/1997
LexicalTag ABB
ThesaurusID NLM (2008); gamma-PAK
Term UI T279383
LexicalTag NON
ThesaurusID NLM (2008)

p21-Activated Kinase 1 Narrower

Concept UI: M0249429
Registry Number: EC 2.7.11.1
Terms: p21-Activated Kinase 1 Preferred Term
Term UI T279434
LexicalTag NON
ThesaurusID NLM (2008); Serine-Threonine-Protein Kinase PAK 1
Term UI T688770
Date01/04/2007
LexicalTag ABX
ThesaurusID NLM (2008); alpha p21-Activated Kinase
Term UI T452449
Date06/26/2001
LexicalTag NON
ThesaurusID NLM (2008); alpha-PAK
Term UI T452450
Date06/26/2001
LexicalTag ABB
ThesaurusID NLM (2008); PAK1 Kinase
Term UI T279433
LexicalTag ABX
ThesaurusID NLM (2008); PAK-1 Kinase
Term UI T402840
Date12/15/1999
LexicalTag ABX
ThesaurusID NLM (2008)

p21-Activated Kinase 3 Narrower

Concept UI: M0252435
Registry Number: EC 2.7.11.1
Terms: p21-Activated Kinase 3 Preferred Term
Term UI T282440
LexicalTag NON
ThesaurusID NLM (2008); Oligophrenin-3
Term UI T688776
Date01/04/2007
LexicalTag NON
ThesaurusID NLM (2008); Serine-Threonine-Protein Kinase PAK 3
Term UI T688772
Date01/04/2007
LexicalTag ABX
ThesaurusID NLM (2008); PAK3 Kinase
Term UI T688773
Date01/04/2007
LexicalTag ABX
ThesaurusID NLM (2008); beta p21-Activated Kinase
Term UI T452451
Date06/26/2001
LexicalTag NON
ThesaurusID NLM (2008); beta-PAK
Term UI T452452
Date06/26/2001
LexicalTag ABB
ThesaurusID NLM (2008)

p21-Activated Kinases MeSH Descriptor Data 2024