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rho-Associated Kinases MeSH Descriptor Data 2022


MeSH Heading
rho-Associated Kinases
Tree Number(s)
D08.811.913.696.620.682.700.814
D12.776.476.563.814
Unique ID
D054460
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D054460
Scope Note
A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.
Entry Term(s)
ROCK Protein Kinases
ROCK-I Protein Kinase
ROCK-II Protein Kinase
ROK Kinase
p160 rhoA-Binding Kinase ROKalpha
p160ROCK
rho-Associated Coiled-Coil Containing Protein Kinase 1
rho-Associated Coiled-Coil Containing Protein Kinase 2
rho-Associated Coiled-Coil Kinase
rho-Associated Kinase
rho-Associated Kinase 1
rho-Associated Kinase 2
rho-Associated Kinase alpha
rho-Associated Kinase beta
rho-Associated Protein Kinase alpha
rho-Associated Protein Kinase beta
rho-Kinase
Registry Number
EC 2.7.11.1
Related Numbers
EC 2.7.11.1
Public MeSH Note
2008; RHO-ASSOCIATED KINASES was indexed under PROTEIN-SERINE-THREONINE KINASES & INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS 1996-2007
History Note
2008
Date Established
2008/01/01
Date of Entry
2007/07/09
Revision Date
2021/05/21
rho-Associated Kinases Preferred
rho-Associated Kinase 1 Narrower
rho-Associated Kinase 2 Narrower
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