Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

Mitogen-Activated Protein Kinase Kinases MeSH Descriptor Data 2025


MeSH Heading
Mitogen-Activated Protein Kinase Kinases
Tree Number(s)
D08.811.913.696.620.682.700.565
D08.811.913.696.620.682.725.200
D12.776.476.563.565
D12.776.476.568.200
Unique ID
D020929
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D020929
Scope Note
A dual-specific protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily.
Entry Term(s)
MAP Kinase Kinases
MAP-ERK Kinase
MAPK Kinase
MAPK Kinases
MAPK-ERK Kinase
MAPK-ERK Kinases
MAPKK
MAPKKs
MEK
MEKs
Map Kinase Kinase
Mitogen-Activated Protein Kinase Kinase
Registry Numbers
EC 2.7.12.2
EC 2.7.12.2
Related Numbers
EC 2.7.12.2
Previous Indexing
Protein Kinases (1989-1999)
Protein-Serine-Threonine Kinases (1993-1999)
Protein-Tyrosine Kinase (1989-1999)
See Also
MAP Kinase Signaling System
Public MeSH Note
2000; MAP KINASE KINASE and MAPKK (now MITOGEN-ACTIVATED KINASE KINASES) were indexed under PROTEIN KINASES 1992-1999; MAP-ERK KINASE (now MITOGEN-ACTIVATED KINASE KINASES) was indexed under PROTEIN-TYROSINE KINASE 1992-1999
History Note
2000; for MAP-ERK KINASE use MEK1 PROTEIN (NM) 1992-1999
Date Established
2000/01/01
Date of Entry
1999/11/03
Revision Date
2021/05/21
Mitogen-Activated Protein Kinase Kinases Preferred
MAPK-ERK Kinases Narrower
page delivered in 0.182s