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Mitogen-Activated Protein Kinase Kinases MeSH Descriptor Data 2023


MeSH Heading
Mitogen-Activated Protein Kinase Kinases
Tree Number(s)
D08.811.913.696.620.682.700.565
D08.811.913.696.620.682.725.200
D12.776.476.563.565
D12.776.476.568.200
Unique ID
D020929
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D020929
Scope Note
A dual-specific protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily.
Entry Term(s)
MAP Kinase Kinases
MAP-ERK Kinase
MAPK Kinase
MAPK Kinases
MAPK-ERK Kinase
MAPK-ERK Kinases
MAPKK
MAPKKs
MEK
MEKs
Map Kinase Kinase
Mitogen-Activated Protein Kinase Kinase
Registry Number
EC 2.7.12.2
Related Numbers
EC 2.7.12.2
Previous Indexing
Protein Kinases (1989-1999)
Protein-Serine-Threonine Kinases (1993-1999)
Protein-Tyrosine Kinase (1989-1999)
See Also
MAP Kinase Signaling System
Public MeSH Note
2000; MAP KINASE KINASE and MAPKK (now MITOGEN-ACTIVATED KINASE KINASES) were indexed under PROTEIN KINASES 1992-1999; MAP-ERK KINASE (now MITOGEN-ACTIVATED KINASE KINASES) was indexed under PROTEIN-TYROSINE KINASE 1992-1999
History Note
2000; for MAP-ERK KINASE use MEK1 PROTEIN (NM) 1992-1999
Date Established
2000/01/01
Date of Entry
1999/11/03
Revision Date
2021/05/21
Mitogen-Activated Protein Kinase Kinases Preferred
MAPK-ERK Kinases Narrower
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