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Proto-Oncogene Proteins c-abl MeSH Descriptor Data 2022


MeSH Heading
Proto-Oncogene Proteins c-abl
Tree Number(s)
D08.811.913.696.620.682.725.500
D12.776.476.568.500
D12.776.624.664.700.167
Unique ID
D016315
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016315
Scope Note
Non-receptor tyrosine kinases encoded by the C-ABL GENES. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal HEMATOPOIESIS especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation.
Entry Term(s)
Proto-Oncogene Proteins abl
abl Proto-Oncogene Products
abl Proto-Oncogene Proteins
c-abl Proteins
Registry Number
EC 2.7.10.2
Previous Indexing
Neoplasm Proteins (1983-1985)
Proto-Oncogene Proteins (1986-1990)
See Also
Fusion Proteins, bcr-abl
Public MeSH Note
91
History Note
91
Date Established
1991/01/01
Date of Entry
1990/06/19
Revision Date
2021/05/21
Proto-Oncogene Proteins c-abl Preferred
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