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RUNX1 Translocation Partner 1 Protein MeSH Descriptor Data 2022


MeSH Heading
RUNX1 Translocation Partner 1 Protein
Tree Number(s)
D12.776.624.664.700.936
D12.776.930.780.625.575
Unique ID
D000075142
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000075142
Scope Note
A transcriptional co-repressor that contains a MYND-type zinc finger (MYND DOMAIN) at its C-terminal and functions as a homo-oligomer. It associates with DNA-binding transcription factors, other repressor proteins, and HISTONE ACETYLTRANSFERASES to repress expression of genes involved in cell growth and differentiation such as MATRIX METALLOPROTEINASE 7 and TCF12. A CHROMOSOMAL TRANSLOCATION involving the RUNX1T1 and CORE BINDING FACTOR ALPHA 2 SUBUNIT (RUNX1) genes frequently occurs in cells of leukemia patients; the resulting fusion protein (AML1-ETO or RUNX1-RUNX1T1) plays a critical role in leukemogenesis.
Entry Term(s)
Eight Twenty One Protein
RUNX1T1 Protein
Registry Number
0
Previous Indexing
DNA-Binding Proteins (1993-2017)
Proto-Oncogene Proteins (1993-2017)
Transcription Factors (2008-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/04/05
RUNX1 Translocation Partner 1 Protein Preferred
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